Nitric oxide for Autoimmune and Chronic Disorders

nitric oxide and inflammation

When it comes to autoimmune disease, taming inflammation is the name of the game. This can be difficult because the body creates vicious cycles where inflammation keeps feeding more inflammation. This makes halting the progression of thyroid or hormone imbalances difficult…but not impossible.

nitric oxide inflammation copyHowever, we now know about nutritional ingredients that can boost anti-inflammatory efforts. These ingredients act on two inflammatory immune messengers called “nitrous oxide” and “IL-17.”

IL-17 is a pro-inflammatory immune cell that damages body tissue, such as the thyroid gland in autoimmune Hashimoto’s, the joints in rheumatoid arthritis, or the nerve sheaths in multiple sclerosis. IL-17 isn’t completely bad—it’s necessary to fight infection. But when the immune system becomes hyper zealous, IL-17 goes out of control and attacks the body it’s designed to protect.

IL-17 destroys tissue by activating a “inducible nitric oxide,” one of three forms of nitric oxide, a gas, involved in various processes in the body. Two other two forms of nitric oxide are beneficial and actually fight inflammation: endothelial nitric oxide and neuronal nitric oxide.

However, inducible nitric oxide is pro-inflammatory and damages body tissue under the orders of IL-17.

Therefore, one way we can stop the vicious cycle of inflammation is to dampen IL-17 and inducible nitric oxide. Luckily, there are nutritional compounds that help the body do this.

But first — perhaps you’ve heard of arginine to boost nitric oxide. Although arginine boosts the anti-inflammatory endothelial and neuronal nitric oxides, it also boosts inducible nitric oxide. So if you are fighting chronic inflammation, taking arginine may work against you.

It’s safer instead to take nutritional compounds that studies show support endothelial nitric oxide. These include:

  • Adenosine
  • Huperzine A
  • Vinpocetine
  • Alpha GPC
  • Xanthinol niacinate
  • L-acetylcarnitine

These compounds work synergistically taken together in an emulsified liquid form. Not only does boosting endothelial nitric oxide tame inflammation associated with Hashimoto’s hypothyroidism, it also helps repair and regenerate body tissue, promote blood flow, dissolve plaques, and dilate blood vessels. Start with small doses to gauge effects and tolerance. These compounds also support neuronal nitric oxide and thus the health of your brain and nervous system.

Exercise is another excellent way to boost beneficial nitric oxides. In fact, take these endothelial nitric oxide boosting compounds before getting your heart rate to maximum capacity for a few minutes first thing in the morning. This will optimize anti-inflammatory effects, support brain health, and help better manage .

You don’t have to exercise long — just a few minutes of raising your heart rate as high as you can has profound anti-inflammatory and brain supporting effects. Just be sure not to over train as that produces more inflammation. Also, how you get your heart rate up depends on your fitness level and abilities, so keep it safe and doable.

Other tools to tame inflammation  include therapeutic doses of vitamin D3, omega 3 fatty acids, absorbable forms of glutathione  and therapeutic doses of emulsified resveratrol and curcumin. These compounds have been shown to dampen the the inflammatory vicious cycles associated with autoimmune disorders.

Of course, lifestyle and diet changes are vital too. This includes eliminating pro-inflammatory foods with the autoimmune diet and designing an inflammation-quenching lifestyle.

For help taming your chronic inflammation, contact my office for advice.

Joni Labbe

About Joni Labbe

Dr. Joni Labbe is a board-certified clinical nutritionist specializing in science-based nutrition with a focus on women's health issues. She has successfully helped pre-menopausal and menopausal women regain and maintain their health since 1995. Dr. Labbe is the author of the Amazon #1 Best Selling book Thyroid & Menopause Madness and It’s Not Just Menopause: It’s Your Thyroid. She is also a professional speaker, radio personality, fitness expert, and former host of “Healthier Way With Dr. Labbe.” Dr. Labbe is one of the country’s leading authorities on thyroid disorders, including Hashimoto’s disease. Dr. Labbe has also authored numerous articles and blogs on health, nutrition, and thyroid health, as seen in Naturally Savvy, Thyroid Nation, and Fox News. She is a Board Certified Clinical Nutritionist, Doctor of Chiropractic, and has post graduate training in Functional Neurology, Functional Endocrinology, Functional Blood Chemistry Analysis, and earned a Diplomate and Fellow in Nutrition from the American Association of Integrative Medicine.

Leave a Reply

*